ITD GmbH and ELEX Commerce jointly developed a module which allows the production of radio-iodine using medical PET cyclotrons (TERIMO = TeO2 based Radio-Iodine separation Module). The module has been specifically developed for the production of 124I for PET; however other radionuclides of iodine, e.g. 123I, can be produced as well. The production technology is based on irradiation of highly enriched tellurium oxide targets 124TeO2 for 124I and 123TeO2 for 123I, respectively) using the COSTIS target station that is commercially available from IBA S.A., Louvain-la-Neuve, Belgium. This target station may be adapted to any of the existing PET cyclotrons.
The heart of the module is a specially developed very small quartz furnace that is optimized for minimal heat release, fast dynamic behavior in temperature regulation, low inner dead volume and small trapping volume. The furnace is operated automatically providing a dedicated and optimized temperature protocol.
The irradiated target disc (Pt that carries the TeO2 target material) is inserted manually into the target holder with a suitable distance tool and the furnace is closed. All further operations (temperature program and delivering and control of gas flow and liquids) are fully automated and remotely controlled. An automatic cleaning program is provided. The process is fast (~30 minutes) providing high radiochemical yields (>95 %) and high radio-iodide concentration (trap volume 0.5 – max. 1 ml). Losses of the expensive enriched target material are negligibly low (< 0.2 mg/per cycle). The whole operation of the module is GMP compliant.
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